I use Seafoam in everything I own... Will it quiet a noisy lifter? Not sure on that but I do from time to time add it in my oil at about 500 before an oil change to let it clean out the motor.
I use it in the fuel every oil change I do...
Gas mileage is awesome and not sure if their has ever been a poll on here, but with my 2005 Tahoe when I go on vacation and set the cruise control at 72MPH I am just breaking over 20MPG still with just over 75k on it. Sticker says 18, but on the next fill up doing the math I am getting that... I do use and have been using full synthetic oil since the break in when I dumped the oil at 500 miles. Did the usual to the truck with things breaking, but motor still sounds great and hoping to get another 75K on it