It is never foolish to switch to synthetic for reasons of logevity, wear, or performance. There is some debate if over the long haul there is a return on your investment if you are looking to increase mileage enough to pay back for the extra cost of synthetic fluids. I run Mobil 1 over RP pased on the 2 bucks a quart extra for RP. I want to run synthetic in the transmission but I just don't know which one is best for that application yet. When I change the fluid in the rear diff I will either use Mobil 1 gear lube, Royal Purple, or Red Line's recomendation.
You will also be happy to know that your contribution is neither contributing to Middle East terrorism or the E85 scam by purchasing sythetic lubrication.